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Onset and duration of action of sildenafil for the treatment of erectile ... Onset and duration of action of sildenafil for the treatment of erectile ...
In healthy volunteers, sildenafil doses are absorbed rapidly, with maximum plasma concentrations achieved within a median time of 1 h (range, 0.5–2 h) after ...

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The total duration of erections recorded during rigiscan monitoring or from the patients self-assessments during 60 min of vss was determined in both studies. The proportion of responders was calculated for the sildenafil and placebo treatment groups and was analysed (study ii) using the mainland-gart test for treatment effect. The ability to achieve penile erection is dependent on several factors, including relaxation of corpus cavernosal smooth muscle, increased vascular blood inflow and restricted venous outflow in the penis.

When vss commenced 2 h after dosing, the median total duration of grade 3 or 4 erections for patients receiving sildenafil was 19. Among the 14 sildenafil responders, the median duration of erections was 11. Department of urology, st james university hospital, leeds, west yorkshire, uk ian eardley, department of urology, st james university hospital, beckett street, leeds, west yorkshire ls9 7tf, uk, tel.

The patients were asked to record all erections during vss and to grade the degree of hardness on a scale of 14 grade 1 an increase in penis size but not hardness grade 2 hard but not hard enough for penetration grade 3 hard enough for penetration but not completely hard grade 4 completely hard. Sildenafil an orally active type 5 cyclic gmp-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Sixteen patients, none of whom had participated in study i, entered study ii.

Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. Visual sexual stimulation (vss) began 10 min after dosing with study medication and lasted for 60 min. During stimulation, nonadrenergic-noncholinergic neurones and vascular endothelial cells release no, which activates guanylate cyclase, thereby increasing the level of cgmp in the corpus cavernosum sildenafil citrate (viagra, pfizer) is a selective inhibitor of cgmp-specific phosphodiesterase type 5 (pde5), a pde isozyme found in high concentration within the corpus cavernosum.

For the placebo responders, the median total duration of grade 3 or 4 erections was 0 min (range 027 min) and the mean was 3. The time to onset of erections after sildenafil (50 mg) or placebo dosing following visual sexual stimulation (vss) was assessed in 17 patients. Clinical safety of oral sildenafil citrate (viagra) in the treatment of erectile dysfunction.

In contrast, the median duration for patients receiving placebo was 0 min (range 023 min), and the mean duration was 3. Before enrolment, patients underwent a physical examination, a 12-lead electrocardiogram and standard laboratory tests. Median time to onset of erections with 60 rigidity during visual sexual stimulation as determined using data derived from rigiscan monitoring of penile rigidity in study i. The duration of grade 3 (hard enough for penetration) and grade 4 (fully hard) erections, determined by self-assessment during 60 min of vss starting 2 and 4 h after sildenafil (100 mg) or placebo dosing, was measured in 16 patients. Evaluation of real-time rigiscan monitoring in pharmacological erection.


High dose sildenafil citrate as a salvage therapy for severe erectile ...


The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum ...

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A risk-benefit assessment of sildenafil in the treatment of erectile ...
Drug Saf. 2001;24(4):255-65. A risk-benefit assessment of sildenafil in the treatment of erectile dysfunction. Vitezic D(1). Author information: (1)Clinical ...
Viagra Maximum Benefits Unemployment Department of urology, st james university hospital, leeds, west yorkshire, uk ian eardley, department of urology, st james university hospital, beckett street, When vss began 4 h postdose, the median duration was 5 min (045) for sildenafil compared with 0 min for placebo (027). Rigidity measurements made using the rigiscan were shown to be reproducible over a 3-night span in healthy volunteers in the second study, fasted patients received four treatments and underwent four assessments, The mean age was 52 years (range 3770 years). Among all patients treated with sildenafil, An objective evaluation of psychogenic factors leading to ed may serve to direct the patient to the appropriate therapy. The study consisted of two parts each part was divided into two treatment periods in which the patients received a single oral 100-mg dose of sildenafil, the maximum recommended therapeutic dose, or placebo. This is an appropriate period of therapeutic activity that is realistic and convenient for most couples.
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    A total of 17 patients entered study i. The physiological mechanism is mediated via a nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. Median values for assessments of time to onset and duration of erections were calculated. In the first study, fasted patients received a single oral 50-mg dose of sildenafil, the recommended therapeutic starting dose, or matching placebo, followed by a 7-day washout period, after which they received a single dose of the alternate study drug. Of the nine placebo responders, seven (78) responded within 30 min postdose, one (6) within 3144 min postdose and one (6) within 4570 min postdose.

    Sildenafil is an effective oral treatment for ed that produces a penetrative erection as early as 12 min and for most patients, within 30 min after dosing, and a duration of action lasting at least 4 h. This finding reflects the time to peak plasma concentration of sildenafil after oral dosing (30120 min) erections also were achieved when vss was delayed for 2 or 4 h after patients received 100-mg doses of sildenafil. Desirable characteristics of an oral treatment for ed include pharmacokinetic properties that allow a prompt onset of clinical effect and several hours of clinical activity after administration of a single dose, in addition to reliable efficacy and a favourable safety profile at recommended doses. Among the nine placebo responders, the median duration of erections was 7. In clinical practice, it would be worthwhile to perform nocturnal penile tumescence and rigidity testing in patients presenting with ed of no organic cause and a history suggestive of psychogenic causes.

    Results of the patients self-assessments of the median duration of grade 3 or 4 erections were similar to those derived from the rigiscan data. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. Patients aged 3570 years with a clinical diagnosis of ed of no known organic cause (as evidenced by the presence of nocturnal erections, erections of penetrative rigidity under any circumstance or a positive response to an intracavernosal prostaglandin e dose of 20 g or a papaverine dose of 40 mg) of at least 6 months duration were included in the studies. The terminal half-life of sildenafil is 35 h therefore, the drugs therapeutic response is expected to be sustained for at least 3 h following a dose of 100 mg. The objectives of this study were to evaluate the efficacy and tolerability of high dose sildenafil as a salvage therapy for patients refractory to the maximum recommended dose of sildenafil. Visual sexual stimulation (vss) began 10 min after dosing with study medication and lasted for 60 min. The proportion of treatment responders was 75 (12 patients) for those receiving sildenafil and 31 (five patients) for those receiving placebo ( 0. Patients self-assessments of total mean durations of grade 3 and 4 erections were analysed using an analysis of variance ( ) model appropriate for a two-treatment, two-period crossover design (study i). This is an appropriate period of therapeutic activity that is realistic and convenient for most couples.

    See risks and benefits of VIAGRA® (sildenafil citrate) . ... the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.

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